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Saturday, August 1, 2020 | History

2 edition of Interactions between platelets and vessel walls found in the catalog.

Interactions between platelets and vessel walls

Interactions between platelets and vessel walls

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Published by Royal Society in London .
Written in English

    Subjects:
  • Blood platelets -- Congresses.,
  • Blood-vessels -- Congresses.,
  • Endothelium -- Congresses.

  • Edition Notes

    Statementa Royal Society discussion organized by G.V.R. Born and J.R. Vane, held on 20 and 21 November 1980.
    ContributionsBorn, G. V. R., Vane, J. R., Royal Society.
    Classifications
    LC ClassificationsQP97
    The Physical Object
    Paginationviii,412p.,(3)leaves of plates :
    Number of Pages412
    ID Numbers
    Open LibraryOL21544541M
    ISBN 100854031642

    Most patients with cerebrovascular diseases are treated with antiplatelet drugs. Basic thromosis research showed that platelets are an important factor in the pathogenesis of ar- therosclerosis and its complications, but other compounds as macrophages and vessel wall factors are . Minor injury to the vessel wall brings into play interactions between platelets and the wall. Platelet adhesion and aggregation ensue, modulated by a number of factors and substances. More severe injury to the vessel wall exposes the blood to other thrombogenic substances. Platelet deposition is also affected by rheologic (blood flow) factors.

    Platelet-vessel wall interactions. London ; New York: Springer-Verlag, © (OCoLC) Online version: Platelet-vessel wall interactions. London ; New York: Springer-Verlag, © (OCoLC) Material Type: Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors: R Michael Pittilo; S J Machin. COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

    Abstract. Platelets are essential mediators of the physiologic process of hemostasis and pathologic thrombosis. While platelets do not interact with vascular walls under normal conditions, vascular injury or inflammation result in a coordinated series of events including platelet adhesion, aggregation, and promotion of coagulation. Platelet-Vessel Wall Interactions. by. The Bloomsbury Series in Clinical Science. Share your thoughts Complete your review. Tell readers what you thought by rating and reviewing this book. Rate it .


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Interactions between platelets and vessel walls Download PDF EPUB FB2

Platelets are essential mediators of the physiologic process of hemostasis and pathologic thrombosis. While platelets do not interact with vascular walls under normal conditions, vascular injury or inflammation result in a coordinated series of events including platelet adhesion, aggregation, and promotion of coagulation.

In this review, we describe the primary mechanisms involved in these Cited by: The interactions between platelets and vascular walls mediate the physiologic process of hemostasis as well as the pathologic entity of thrombosis.

These phenomena demonstrate key differences among vascular beds, and between macro- and microvessels. As outlined in this review, a large number of aspects of hemostasis and thrombosis remain as areas of active investigation.

P-selectin and PSGL-1 constitute the main receptor-ligand pair that mediates physical interactions between platelets and leukocytes. The binding allows efficient leukocyte recruitment at the site of vascular injury, and the formation of mixed platelet-leukocyte conjugates in circulating blood, 19 Their adhesive interaction also triggers fibrin formation and thrombus growth by concentrating Cited by:   Platelets circulate in blood in a resting state, but they are able to react immediately upon a vessel wall injury by adhering to the exposed collagen, followed by platelet–platelet interaction to form a plug that effectively seals the injured vessel wall to prevent excessive blood by: The circulatory system is lined by vascular endothelium which has a central role in maintaining the integrity of the vessel wall and prevent­ ing thrombosis.

The natural equilibrium existing between normal en­ dothelium which supports blood flow, and platelets which serve to re­ pair damaged endothelium, is explored in the first two chapters. Platelets, Thrombosis and the Vessel Wall aims to highlight the key areas of platelet function in the regulation of haemostasis and thrombosis and covers areas such as platelet production, interaction of platelets with leucocytes, mechanisms of cross-talk between platelets.

Although VWF-GPIb interactions can resist high shear, the binding is transient and, as a result, fast-flowing platelets will slow down and roll over the vessel wall, allowing interaction of other platelet receptors with matrix proteins leading to stable platelet adhesion (Fig.

1 part 1). Download: Download high-res image (1MB). Role of Platelet-Leukocyte Interactions. Leukocytes are key mediators in the inflammatory response, and interactions between leukocytes and platelets are increasingly recognized as relevant for inflammation and thrombosis.

Figure depicts several proposed mechanisms by which platelet-leukocyte interactions contribute to thrombosis. The physiologic role of the putative platelet PSGL-1 and of endothelial PSGL-1 on platelet-vessel wall interactions remains to be established.

Another proposed mechanism of platelet adhesion to endothelium in inflammation is via platelet GPIIb/IIIa, through its known interaction with fibrinogen [ 85. Excessive numbers of platelets, and/or normal platelets responding to abnormal vessel walls, can result in venous thrombosis and arterial thrombosis.

The symptoms depend on the site of thrombosis. Tests of function Bleeding time. Bleeding time was first developed as a test of platelet.

This regulated physiological process consists of complex interactions between endothelial cells, platelets, von Willebrand factor and coagulation factors. Haemostasis is initiated by a damaged vessel wall, followed with a rapid adhesion, activation and aggregation of platelets to the exposed subendothelial extracellular matrix.

Since the interaction between vWF and GPIb–V–IX is transient, this will result in the slowing down and subsequent rolling of platelets over the injured vessel wall. (2.) The rolling platelet. The publication of Platelet-Vessel Wall Interactions, the second monograph in the Bloomsbury Series in Clinical Science, is particu­ larly welcome as its appearance signifies the further development of the Series and its potential for the future.

The theme of this monograph is the pathophysiology. Interactions of blood elements with vascular walls mediate the related processes of hemostasis and thrombosis. Hemostasis is the physiological arrest of hemorrhage at the site of vascular injury. It is orchestrated by the concerted response of platelets, the vessel wall and coagulation factors.

Thrombosis refers to pathological formation of blood clots due to inappropriate activation of. Physiology in Medicine from The New England Journal of Medicine — Arachidonic Acid Metabolites and the Interactions between Platelets and Blood-Vessel Walls logo logoCited by: The interactions of leukocytes and platelets with the vessel wall, such as occur in inflammation, are highly dynamic and often transient.

The development of intravital microscopy was the spark that allowed real-time observations of blood cells in live animals, and led to the detection and molecular analyses of their interactions with the vessel wall.

Book Description. Platelets, Thrombosis and the Vessel Wall aims to highlight the key areas of platelet function in the regulation of haemostasis and thrombosis and covers areas such as platelet production, interaction of platelets with leucocytes, mechanisms of cross-talk between platelets.

Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis (Colloquium Integrated Systems Physiology: From Molecule to Function to Disease) [Rumbaut, Rolando, Thiagarajan, Perumal, Granger, D.

Neil, Granger, Joey] on *FREE* shipping on qualifying offers. Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis (Colloquium Integrated Systems Physiology: From Reviews: 1. Appropriate hemostasis hinges on normal vascular control of platelet function to suppress thrombosis in the absence of blood vessel injury.

In this regard, normal intercellular communication between vascular endothelial cells and platelets is integral to maintaining platelets in an inactivated state and inhibiting maladaptive clot (thrombus.

Sakariassen KS, Aarts PA, de Groot PG, Houdijk WP, Sixma JJ: A perfusion chamber developed to investigate platelet interaction in flowing blood with human vessel wall cells, their extracellular matrix, and purified components. J Lab Clin Med –, Google Scholar.

Platelets - winner of a Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine.

Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases. Once tethered to the vessel wall, platelets form irreversible adhesion bonds through the interaction of platelet receptors with specific subendothelial matrix proteins and plasma proteins.

They remain patent and functional for over two weeks and perhaps longer. Because of the ability to employ complex geometries and controllable flow, these synthetic microvessels are ideal tools to study in detail the interactions between platelets and the vessel wall in a way that mimics various scenarios of microvascular thrombosis.